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In contrast, the only parallel mutations that exclusively occurred in periods of stasis (red intervals) were also the only ones to occur in non-epitope regions of the HA protein.
Consequently, one might speculate that the two UCP3 mutations that exclusively mimicked the wild-type UCP3 in sequestration of either intracellularly released (UCP3R167G) or entering Ca2+ (UCP3RE171/172GG) might exhibit different Ca2+ sensitivities.
In this case, there are no mutations that exclusively occur in P′.
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We have not identified a mutation that exclusively abolishes PhoQ activation by CAMP without perturbing the response to acidic pH and/or divalent cation limitation.
We analysed only those germline mutations that are exclusively associated with PCCs germline mutations associated only with phaeochromocytomas (GMEPs; n = 26; 20 PCC-associated germline mutations and six Type 2C VHL disease mutations).
This raises the interesting possibility that these inhibitors might also be appropriate for the treatment of developmental disorders that are caused by RAS mutations that depend exclusively on Raf-MAPK activation to convey their pathology.
First, despite its frequent co-deletion with CDKN2A, germline or acquired mutations that target CDKN2B exclusively have not been observed [ 49, 50].
Mutations that were initially exclusively present in CTC were found by additional deep sequencing to be present at subclonal level in the primary tumours and metastases from the same patient (Heitzer et al, 2013).
Second, in the 2-Mb critical region, HOXA1 c.451delisstheis the only protein-altering mutation that occurs exclusively in Chinese Shaziling pig and the Erhualian×Shaziling F2 family.
Comparing DNA from the brains of 23 Alzheimer's patients against 40 healthy brains matched for age, the team found one mutation that occurred exclusively in Alzheimer's brains--65 brains--65 brains--65%ntained this mutatiof, the team reports online this week in the Proceediseased the National Academy of Sciences.
In particular, we need mutations that perturb interdomain contact, exclusively, without perturbing the binding affinity of WW domain residues.
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CEO of Professional Science Editing for Scientists @ prosciediting.com