Sentence examples for mutations that evolved from inspiring English sources

DOI: http://dx.doi.org/10.7554/eLife.09696.009 To understand the effects of the other gltA mutations that evolved in the Ara 3 population, we examined the enzymatic activity of citrate synthase (GltA).

The presence of the gltA1 mutation is beneficial to fitness in DM25 in one of these two strains, each of which contains other mutations that evolved before and after gltA1 during the LTEE.

A high concordance between ESR1 mutations that evolved in PDX and human tumors bolsters our confidence in using PDX as a reliable model for evaluating novel therapeutic strategies for treatment of endocrine therapy resistance that evolved in the background of ESR1 mutations.

The serial transfer phase of the recombinant mix purges mutations that evolved under continuous culture but are detrimental in the serial transfer regime (Nguyen et al. 2012).

These mutations were likely present in the MA experiment ancestor, so we generated an updated ancestral genome sequence incorporating these changes and used this as input into breseq to predict new mutations that evolved independently in each of the 21 MA lineages (Additional file 2).

One interpretation is that each new pose is a mutation that evolved de novo.

Then, we use breseq to identify mutations leading to structural variation that evolved during an evolution experiment with E. coli K-12 that was previously used to estimate the spontaneous rates of mutations leading to SNVs and indels in this organism.

The Fisher-Muller model predicts that in asexuals (non-recombining individuals) two beneficial mutations have to be fixed sequentially, whereas recombination can combine beneficial mutations that have evolved in parallel.

EP theory predicted that none of the codons that evolved mutations providing resistance against pyrimethamine would be under extreme purifying selection, and this was demonstrated in this study.

(E ) Linear schematic of Rasgrp1 protein domains, phosphorylation site threonine 184, and position of R519G mutation in the second EF hand that evolved into a domain for autoinhibition.

Further addition of the gltA2-R mutation that evolved in a Cit++ genetic background greatly inhibits growth in this genetic background that cannot utilize citrate.