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Models based on mutation-selection balance theory predict that this observed variation will be due to rare alleles at many loci introduced through random mutations that evolution acts on to eliminate through persistent purifying natural selection (Kimura, 1968; Turelli, 1984).
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We aimed to identify those mutations that facilitate enzymatic evolution, but might not directly increase catalytic efficiency.
Yet clearly there are random events in Nature, and a vast body of science is based on them, from the random collision of atoms to the random mutations that drive Darwinian evolution.
Two new motifs, probably resulting from favorable mutations that occurred during evolution, were identified; from both motifs: FDYWGKGTMVTVTS and FDYWGKGTKVTVSS.
Indeed, because the mutations that lead to evolution and/or speciation occur purely by chance, they will only ever occur very rarely.
However, I will revisit the question of the nature of the mutation that drives evolution.
Thus, in a global sense, the mutation that drives evolution as described in this paper is still random.
To make this explicitly clear, the traditional idea of the mutation that drives evolution is that mutation is the result of accident.
a By defining the mutation that drives evolution as described in this paper, I do not mean that this mutation is nonrandom in a global sense.
We will take this to mean that the mutation that drives evolution is the result of an organic process that belongs to the organism.
This paper holds that the mutation that drives evolution is not a result of random accident but an outcome of a mutational writing phenotype.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com