Sentence examples for mutations that endow from inspiring English sources

Studies that have used massively parallel sequencing have shed light on the rich functional landscape of mutations that endow tumour cells with the ability to evade T-cell-mediated immunosurveillance.

Furthermore, the existence of variant cells creates an essential substrate for in vitro selection whereby mutations that endow cells with improved growth outcompete their normal counterparts and overtake the culture a phenomenon termed culture adaptation (Baker et al., 2007; Enver et al., 2005).

A bigger challenge is to specify mutations that endow a new function, such as a lost functionality in a duplicated gene.

Ongoing genomic instability in cells such as CICs can subsequently allow for outgrowth of unique subclones, which acquire additional driver mutations that endow them with a selective growth advantage (Hanahan and Weinberg, 2011).

These two properties drive protein remodelling during evolution wherein a trade-off exists between mutations that endow better protein function regardless of protein fitness and compensatory mutations that improve stability [ 7].

Protein pairs included in the experimental sets are endowed with an average number of mutations that is very small with respect to the pairs included in the training set.

To shed light into these principles, in this work we combined structural studies by X-ray crystallography with a rescue approach using a Syt1/7 chimera that cannot rescue neurotransmitter release in synaptotagmin-1 neurons, and attempted to endow the chimera with rescue activity with mutations that make the synaptotagmin-7 C2B domain more similar to the synaptotagmin-1 C2B domain.

Mutations that add or change function?

Somewhere among the genetic disparities must lie the mutation or, more probably, mutations that define us.

The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.

Evolution depends on mutations that simply don't have direction.