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The hope is to identify the causative mutations that drive each type of cancer.
Scientists are now attacking specific mutations that drive specific forms of cancer.
For the last decade or so, the emphasis in oncology has been so-called targeted therapy, in which drugs counteract particular genetic mutations that drive tumor growth.
NGS and other nucleic acid sequencing technologies (reviewed in [3, 4]) have identified genetic mutations that drive lung cancer progression often referred to as "oncogenic drivers".
The study of genomic aberrations and the identification of somatic mutations that drive a particular malignancy are, therefore, fundamental to the understanding of tumour biology.
Unlike conventional chemotherapy, which attacks all rapidly dividing cells, targeted drugs focus on the genetic mutations that drive cancer growth.
Similar(24)
This may be a consequence (as detailed above) of the underlying mutations that drove the original transformation and immortalisation of the parental BL31 cell line, clonal selection pressures associated with establishing LCLs, and the alternative differentiation states of the two cell types.
Note that the causative mutation, or the combination of mutations, that drove this sweep does not necessarily have to lie inside the analyzed window but could also be located elsewhere in the genome.
In half the cases, the tests have found a mutation that drives the cancer.
However, I will revisit the question of the nature of the mutation that drives evolution.
Thus, in a global sense, the mutation that drives evolution as described in this paper is still random.
More suggestions(15)
breakthroughs that drive
mutations that produce
mutations that cause
mutations that occur
mutations that allow
mutations that account
mutations that are
mutations that improve
mutations that have
mutations that indicate
mutations that start
mutations that seem
mutations that destroy
mutations that change
mutations that make
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com