Sentence examples for mutations that displayed from inspiring English sources

This model revealed that the mutations that displayed the greatest in vivo UV sensitivity in Drosophila did not correlate with those that led to tumor formation in humans.

For the remaining five conserved mutations that displayed altered Kd values (Ser-177, Ser-182, His-185, Thr-186, Gln-188), there was no corresponding change in affinity for the Ala mutants, indicating that it was not the chemical characteristics of the residue that was critical at these positions.

This and other redundant functions of LIN-35 were identified in genetic screens for mutations that display synthetic phenotypes in conjunction with loss of lin-35.

Generally speaking, mutations that display low penetrance also tend to exert milder effects on the clinical phenotype and/or protein function, while the more highly penetrant a mutation is, the less frequent it is likely to be in the general population (Coventry et al. 2010; Marth et al. 2011; Gorlov et al. 2011; Tennessen et al. 2012; Nelson et al. 2012; Subramanian 2012; Fu et al. 2013).

Expression of this variant in Xenopus oocytes showed alterations in activation and deactivations kinetics, but the changes were relatively mild compared with the previously reported KCNC3Phe448Leu mutation that displayed a much more significant gain-of-function in our heterologous expression system [6].

In this line and as a proof of principle we introduced a histone point mutation that displayed enhanced autophagy during aging.

From the calculated iP and molecular weight (Mw) for the mutated and non-mutated contigs that displayed non-synonymous mutation, the variation in iP ranged from -1.95 to 1.09, and the Mw from -97.11 kDa to 66.08 kDa.

Because mutants A1, B2 and D2 contained only single or double mutations that readily displayed high-affinity [H]granisetron binding, we reasoned that these subtle changes alone are sufficient to mimic the 5-HT3R-binding site.

Additionally, two mutations (S516D and T536A) that displayed normal activation with ACh displayed remarkable reductions in sensitivity to nicotine.

This study showed that each tumour harboured mutations in ∼90 genes that displayed significant heterogeneity between tumour types.

By screening for individual amino acid mutations in HIV protease that displayed positive selection, this metric was able to correctly predict 19 out of 23 known drug resistance mutation sites in HIV protease [ 10].