Sentence examples for mutations that directly from inspiring English sources
Chance mutations that directly reverse or otherwise suppress the earlier mutator-like mutations in Geraniaceae may be favored and fixed by natural selection.
And a stronger link to mutations that directly cause disease would strengthen the case.
We find that when intermediates are close to neutral, a large population can cross even wide fitness valleys remarkably quickly, so that valley-crossing dynamics may be common even when mutations that directly increase fitness are also possible.
Exceptions were made for major mutations that directly contribute to causing resistance.
1) Drug treatment selects for mutations that directly cause drug resistance (called primary mutations), many of which may have secondary effects such as reducing protein stability and/or other aspects of viral fitness.
Although incidents are rare in the population, they are examples of germline mutations that directly involve heterofamilial tumorigenesis.
One of the possibilities might be that the silent polymorphism is in linkage with another genetic mutation that directly affects breast cancer phenotype.
Therefore, the induction of programmed necrosis in apoptosis-resistant cell lines in the absence of caspase inhibitors would only be effective in tumors that carry a mutation that directly inactivates caspase-8.
To explore state dependence, we generated gain-of-function mutants based on mutations previously shown to increase the open probability of Slo1 channels: R196Q is equivalent to an S4 mutation that enhances voltage activation (Diaz et al., 1998), whereas F304Y is analogous to a pore mutation that directly increases open probability (Lippiat et al., 2000).
Thus, R403Q is one of the few FHC mutations that can directly affect actin binding.
Although further studies on the full-length domain II of the WT and D320E NS5A proteins will be required to elucidate the precise structural origin of this conformational inversion, our observations suggest that CypA resistance arises by mutations that affect directly the conformation of domain II of the NS5A protein.
