Sentence examples for mutations that diminished from inspiring English sources

Rather than deletion, we identified T cell epitopes in domain II and used alanine substitutions to identify point mutations that diminished those epitopes.

The novel RIT, LMB-142 contains a 38 kDa toxin and nine point mutations that diminished T cell response to the corresponding peptides by an average of 75%.

Interestingly, Bud3p-M19m2 Bud3p-M19m319m3 mutantshoweded prominent nuclear localization (Fig. 5C, right panel), suggesting that mutations that diminished PM binding strengthened nuclear targeting.

A recent study has shown that substantial improvements in the pharmacological profile of Xigris® can be achieved by mutations that diminish its inactivation by serpins, underscoring the importance of optimization efforts to create biologics with improved clinical profiles.

More recently, fluoroquinolone resistance has emerged in E. coli and other Enterobacteriaceae, contingent on multiple mutations that diminish the affinity of its topoisomerase II and IV targets in varying ways, reduce permeability, and upregulate efflux (3 ).

Small percentages of Europeans and Asians have a genetic mutation that diminishes the production of filaggrin, an epidermal protein that helps to lock moisture into the skin and keep out pathogens, allergens, and chemicals.

To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple mutations (FGF1ΔHBS) that diminished its ability to induce heparan sulfate (HS -assisted FGF receptor (FGFR) dimerization and activation.

However, even among rare SNPs there exists a minor subgroup of "older" mutations that have diminished their frequency to rare events.

Mutations that diminish the function of the extracellular matrix receptor Dystroglycan (DG) result in muscular dystrophies, with associated neuronal migration defects in the brain and mental retardation e.g. Muscle Eye Brain Disease.

This strain had been derived from reference strain 26695 [40] by five sequential cycles of selection for increased resistance, each cycle associated with a new mutation that likely diminished the ability of cells to chemically reduce Mtz from prodrug to bactericidal agent (genes involved were rdxA, frxA, mdaB, ribF and fur) [20].

These data indicate that the que mutation is a loss-of-function allele that diminishes or abolishes BCKD complex function.