Sentence examples for mutations that determine from inspiring English sources

At the same time, genome-wide analysis of human tumor tissues has made it possible in principle to assess the expression of critical genes or mutations that determine the response of an individual patient's tumor to drug treatment.

"You need to go beyond expression," says OHSU's Druker; researchers need to find specific genetic mutations that determine whether or not these drugs will work.

Protein-coding genes constitute only approximately 1% of the human genome, but harbor ∼85% genetic mutations that determine disease-related traits.

Gareth Morgan Universityy of Leeds, Leeds, UK) reported that personalized medicine is coming, taking into consideration germ line (inherited) or tumor (somatic) mutations that determine response to a particular treatment, and that side effects as well as end-points and survival must be taken into consideration when designing clinical studies.

E200K is unlikely to be the sole mutation that determines CJD onset, since there are some elderly individuals (age, up to 85 years) in this study.

Since the lactase activity is correlated with the population structure, it is necessary to control for the population stratification to correctly identify the mutation that determines lactase persistence.

The lack of knowledge about the true causative mutation(s) that determine the genetic variation of the trait did not allow us to draw this third dimension in our graphical representation.

Recently developed technologies have enabled scientists to identify mutations that define human variability, determine the prevalence of identified genetic mutations in the population, and interpret the function and role of specific genes in disease.

To determine whether nucleotide mutations that define the southeast coastal Texas variant were uniform throughout the quasispecies population of a select isolate, the WN1751/WN2504A PCR product derived from WNV isolate Galveston Co., TX-3, was cloned into pGEM-T Easy.

Next, in order to explore if cancer mutations can hit residues that determine kinase specificity (determinants of specificity [DoS]) and thereby impose downstream rewiring, we included the results from the KINspect algorithm, described in the accompanying article (Creixell et al., 2015), in the ReKINect platform.

When fed a sample of someone's DNA, these spots detect single-letter changes known as "single nucleotide polymorphisms" (SNPs, pronounced "snips").SNPs are single-letter mutations within the DNA that determine how one person is different from another.