Sentence examples for mutations that decrease from inspiring English sources

We find that fixation of sub-threshold male-specific repressive mutations (that decrease CI-levels and lower Wolbachia-prevalence) eases the conditions for the spread of subsequent mutations of similar kind, so that Wolbachia may be lost by way of sequential host adaptation.

TMPRSS6 mutations that decrease its proteolytic activity and prevent HJV cleavage cause increased hepcidin levels that impair iron release from the duodenal enterocytes and macrophages [ 13].

In other words, mutations that increase the stability of the influenza nucleoprotein enable it to tolerate other mutations that decrease its stability, and this phenomenon appears to account for most of the epistasis they observe.

Elevated expression could be a byproduct of increased stability, or it could independently increase mutational robustness by allowing the proteins to better tolerate mutations that decrease codon adaptation or reduce folding efficiency.

The overall balance between the mutational mechanisms that promote repeat expansions and the accumulation of point mutations that decrease repeat purity and therefore decrease the probability of repeat expansion is likely to dictate the nature of the poly-Q tract within a gene and its propensity for allelic variation.

Mutations that decrease the affinity for translation elongation factor eEF1A (but also diminish aminoacylation efficiency) strongly decrease translational enhancement, suggesting that eEF1A is mechanistically involved.

Within the model, cells could acquire selectively advantageous driver mutations, that increased the relative fitness of the cell by a factor of (1+ s d ), selectively disadvantageous housekeeper mutations that decreased fitness by a factor of (1− s h ) and selectively neutral passenger mutations (Fig. 1).

Position 172 was also the only extracellular mutation that decreased surface expression.

With these underlying influences, it is not clear what the effect of a mutation that decreases partially the sensitivity to a mutagenic agent would be regarding extinction.

Therefore, it is possible that a mutation that decreases expression of the B. anynana orthologue of ebony or increases expression of the yellow orthologue could produce the dl phenotype.

In the present report we have addressed this question by investigating whether a mutation that decreases sensitivity of FMDV to R can impede extinction of the virus in the course of cytolytic passages of the virus.