Sentence examples for mutations that create from inspiring English sources

The high-plasticity positions close to the original ("native") active-site are the most promising candidates for mutations that create a second active-site associated to a new function.

Tumor initiation and progression are dependent on rare, stochastic mutations that create genetic variability in a cell population.

But Greaves and colleagues suspected this process could go awry, introducing mutations that create flawed B cells that could cause leukemia.

Moreover, there is increasing evidence that gene loci that harbor GWAS-discovered common variants may also harbor uncommon and rare variants and mutations that create related disease phenotypes [23], [24].

Thus, mutations that create a more hydrophobic environment facilitate the binding of the sugar moiety and promote the transglycosylation and/or the exclusion of H2O resulting in lower hydrolysis activity.

Specifically, bulm757 and bulm421 are point mutations that create STOP codons resulting in shortened peptides missing the last 99 and 219 amino acids, respectively; whereas bulm606 and bulm494 are splice site frame shift mutations resulting in predicted premature stop codons at the beginning of the protein at amino acids 216 and 333, respectively.

In contrast, the GRK7 and GUCY2F pseudogenes were caused by single-point mutations that created single stop codons.

Under this model, mutations that created improved matches to the uptake bias were, over evolutionary time, more often transmitted to other cells by this biased transformation.

However, this simple two-step mutational pathway was apparently inaccessible without the prior evolution of one or more unknown mutations that created a potentiated genetic background (Blount et al., 2008).

Studies have also suggested that new exons appeared initially as minor splicing isoforms, gradually gained functions with time, and became constitutive exons correlated with mutations that creating stronger splice sites [38], [41], [44], [45].

Thus, new exons/introns appearing initially as minor splicing isoforms, may gradually gain functions over time, and became constitutive exons correlated with mutations that creating stronger splice sites.