Sentence examples for mutations that converted from inspiring English sources

We were then able to engineer an in silico mutant channel with three point mutations that converted mVDAC1 into a channel with a preference for cations.

Mutations that convert the normal c-Myb protein into an oncogenic transforming protein also change the spectrum of genes that it regulates [2], [3].

In other NF-κB proteins, such as c-Rel and RelA, site-directed mutations that convert the natural Cys residue (at the position homologous to Cys67 of Nv-NF-κB) to Ser increase the affinity of the protein for a κB site [12] [15].

One experiment looked at the frequency of mutations that convert tRNA-Tyr into ochre suppressor mutations.

Essential causes often abrogate tumor suppressor function, whereas mutations that convert proto-oncogenes into oncogenes tend to be exacerbating causes.

Mutations that convert Ras into an oncoprotein are found in up to 25% of human tumors [ 15] (http://www.sanger.ac.uk).sanger.ac.uk

Many prophage encoded genes are transcriptionally silent, acquire mutations that convert them into pseudogenes and in time undergo degenerative changes and become phage remnants [ 43].

The results might be interpreted by the theory that the gain-of-function mutations that convert proto-oncogenes to oncogenes acts dominantly while the loss-of-function mutation in tumor suppressor genes acts recessively.

Null mutations refer to mutations that convert an amino acid codon into a premature stop codon, or that alter a conserved splice junction and result in premature truncation of the protein product of the gene.

Let the rate of inversion mutations that convert leading strand encoding to lagging strand encoding be u per gene per generation and that of the reverse mutations be v per gene per generation.

The functional significance of the glycine-rich domain has also been reported in Drosophila, where several loss-of-function dALK mutants display point mutations that convert a single glycine residue within the glycine-rich region into an acidic amino acid [ 10].