Sentence examples for mutations that changed from inspiring English sources

The combination of these simple physicochemical properties with a previously described calculation of β-strand contiguity allowed us to design mutations that changed the fibrillogenic propensity of α-synuclein in predictable ways.

In strain F, the missense mutations that changed amino acid residues were detected in pcaD (β-ketoadipate enol-lactone hydrolase), pcaC (γ-carboxymuconolactone decarboxylase), pcaB (β-carboxy-cis,cis-muconate cycloisomerase), and pcaGH (protocatechuate 3,4-dioxygenase), which cleave aromatic rings and catalyze the formation of γ-carboxy-muconolactone and β-ketoadipate enol-lactone.

Two alleles, P864L and S943F, are missense mutations that changed amino acid residues conserved within the genus Drosophila.

Mutations that changed glucose metabolism or acid tolerance conferred no proliferative advantage so that neither phenotypic trait was maintained in the intraductal populations.

Site-directed mutagenesis was used to create point mutations that changed glutamic acid (E) to glutamine (Q) as shown in Figure S1A.

In total, 186 (28.2%) and 110 (16.6%) tumors had somatic mutations that changed the amino acid sequences (non-silent mutations) of KRAS and EGFR proteins, respectively frequencies similar to those previously reported (Heist and Engelman, 2012).

Many scientists think hemagglutinin, and mutations that change its structure, may control where the virus can go and what it can do.

Changes in the food source lead to random mutations that change beak size c.

These range from genetic mutations that change their surface molecules, thereby preventing phage attachment to internal mechanisms blocking phage replication and apoptotic cell-death postinfection to prevent further spread of the phages to neighboring cells (Allison and Klaenhammer 1998).

This is particularly evident in protein domains involved in direct physical interactions with other proteins, where protein interaction may fail if mutations that change the protein structure occur at the site of interaction.

Insertions and deletions are the other types of mutations that change genomic sequences and, therefore, should also be considered.