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Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass.
Sequencing evolved receptors revealed that each contained multiple mutations that altered the amino acid sequence.
To validate whether these encounters are fruitful or futile, we examined three groups of mutations that altered the encounter.
Characterization of P. sojae strains showed that virulent alleles of Avr1b-1 weithertranscriptionallynally silent or had accumulated mutations that altered the ORF and evaded Rps1b surveillance [9].
Rather, it was a hunt for mutations that altered a gene whose biological function was entirely unknown, but the consequence of its mutation was predisposition to certain cancers.
Positive selection on protein-coding genes could raise the non-synonymous substitution rate, as it could drive the fixation of mutations that altered the functional properties of the protein.
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TP53 mutational status was considered as a binary (mutations that alter the coding sequence versus wild type) and ternary (premature chain terminating mutation, missense, and wild type) variable to include possible differences in biology between the types of mutation.
Our analysis pinpoints key residues for mutational analysis, and provides new clues to cancer mutations that alter the canonical modes of ErbB kinase regulation.
The goal in studying the exomes is to identify mutations that alter the amino acid content of a protein, possibly resulting in altered protein function.
Tumor-specific mutated proteins (neoantigens) are another class of tumor antigens, which arise via mutations that alter amino acid coding sequences.
The third change involves mutations that alter the inner contents of the microbe, so that the antibiotic can no longer inactivate its target.
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