Our analysis pinpoints key residues for mutational analysis, and provides new clues to cancer mutations that alter the canonical modes of ErbB kinase regulation.
Tumor-specific mutated proteins (neoantigens) are another class of tumor antigens, which arise via mutations that alter amino acid coding sequences.
Rifampin resistance mutations that alter the efficiency of transcription termination at the tryptophan operon attenuator.
We engineered mutations that alter or remove the zinc binding domain of Escherichia coli RNA polymerase.
To understand how cymes are specified, we studied mutations that alter the petunia inflorescence.
Mutations that alter the expression of these membrane-associated proteins lead to muscular dystrophy (MD) and cardiomyopathy in humans.
The third change involves mutations that alter the inner contents of the microbe, so that the antibiotic can no longer inactivate its target.
Bae, C., Gnanasambandam, R., Nicolai, C. ,Sachs, F. & Gottlieb ,P. A. Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1.
Although both SHM and CSR depend on AID deamination activity, the amino acid mutations that alter the latter may differentially affect these processes (Supplementary Table S1).
Using mutations that alter the positively charged surface-exposed domain, we show that RcsF monitors lateral interactions between lipopolysaccharide (LPS) molecules.
The 'somatic mutation hypothesis' of cancer embraces the notion that neoplastic transformation arises from mutations that alter the function of specific genes (now called oncogenes and tumour-suppressor genes) that are critical for cell division.
