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Mutations that abolish the biogenesis or function of the primary cilium lead to defective Hh signaling [11].
Mutations that abolish the miRNA binding sequence without changing amino acid sequence result in dominant phenotypes for Class III HD ZIPs [12], [13], [21], [22], [23], [24].
In flagellar systems, mutations that abolish cleavage in FlhB also abolish the secretion of flagellin and other late export extracellular components but not early export proteins such as FlgD [27].
Do Gln1 sequences from other yeasts (or sequenced wild S. cerevisiae isolates) contain mutations that abolish the filament-forming phenomenon?
In fact, BRCA1 point mutations that abolish its interaction with CtIP/RBBP8 have been associated with tumor progression [ 27– 29].
Patients with XPG I domain mutations that abolish endonuclease activity suffer from XP, but do not develop CS (Schärer, 2008b).
Similar(27)
To identify this phage-encoded gene product, we screened for ICP1 mutations that abolished miniPLE circularization during infection.
Interestingly, mutations that abolished acetate activity, including the mutation in the well-conserved D(E RY motif, could be rescued by a recently identified synthetic allosteric agonist.
Rates of frameshift mutations that abolished the correct reading frame of this gene were determined by fluctuation analysis.
Mutations that abolished CED-4 oligomerization inactivated its ability to activate CED-3.
A previous study identified a large panel of mutations that abolished PlexinB1-mediated COS7 cell collapse (Bell et al., 2011).
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