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In order to decipher which of these two complex I subunits are best candidate to interact with NDUFA5, we used our previous experimentally supported correlated mutations test (Gershoni et al. 2010).
Second, it is tempting to suggest that the positively selected amino acid in NDUFA5 that divided the south and north chameleon populations reflect an evolutionary response to mtDNA changes in complex I. Indeed, our correlated mutations test highlighted ND5 as the most plausible coevolving partner of NDUFA5, further supporting mito-nuclear coevolution in chameleons.
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Su var)3-9 was chosen because nine of the eleven mutations tested suppressed TPE.
KRAS mutations tested routinely include six mutations in codon 12 and one mutation in codon 13.
Many genetic tests for hereditary hearing loss remain quite variable in methods and mutations tested.
Only one out 7 mutations tested (in lamB) exhibited both reduced fitness and evidence for buffering.
All mutations tested that inhibit the synthesis of ALA increase AtTSPO mRNA steady-state levels.
Of the other mutations tested, only small shifts in EC50 were observed.
The other abi3 mutations tested conferred lesser degrees of sugar-insensitivity.
Similar kinetics were also observed for other mutations tested (Col4a1 +/G394V, Col4a1 +/G658D and Col4a1 +/G1038S; data not shown).
A total of 10 of the 13 mutationsutesteds tested also exhibited differences from the control line.
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