Sentence examples for mutations targeting the from inspiring English sources

They also may include haploinsufficient tumour suppressors, whose partial loss of function contributes to cancer development in the absence of mutations targeting the second wild-type allele4.

Second, more extensive mutations targeting the central appendage either completely disrupted (ΔLQPNP) or reduced (EndoA(Arf -HA) the in vivo function of endophilin-Arf -HA

In conclusion, mutations targeting the central helix-loop appendage on the dEndoA-BAR domain can severely depress survival and spontaneous motor activity of adult flies.

Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC kinase Bub1.

In addition, mutations targeting the aminoglycoside binding site in the 16S rRNA can confer resistance.

DNP-mediated metastasis facilitated by lysine-rich CEACAM1 co-isolated protein (LYRIC) phosphorylation at serine 568 was confirmed using mutations targeting the phosphorylation site of LYRIC.

Di Zenzo, G. et al. Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.

Several of the mutations targeted the essential peptide-binding surface of the BRCA1 BRCT domain.

Two mutations target the FHA and RING finger domain and the third is located in the cysteine-rich region (Fig.  2b).

All mutations targeted the catalytic SET domain leading to a gain-of-function thus offering the possibility of using EZH2 inhibitors.

To verify this hypothesis our mutations targeted the Leu294, we analysed mutants containing three different residues: positively charged arginine, negatively charged aspartic acid and small glycine.