The Playlist this week reported comments from Noomi Rapace, the only human member of the crew of the Prometheus to survive the movie intact and without obvious mutations, suggesting that process is finally under way.
No single viral genome had seven or more drug resistance mutations, suggesting that such severely mutated viruses were too unfit to be detected or that the resistance gain offered by the seventh mutation did not outweigh its contribution to the overall fitness loss of the virus.
Interestingly, 50% of the mutated BCOR patients have DNMT3A mutations suggesting that BCOR and DNMT3A might have role in the pathogenesis of CN-AML with wild type FLT3 and CEBPA [ 30].
CD27 and CD27 developing B cells showed similar Ig heavy chain gene usage with low levels of mutations, suggesting that CD27 developing B cells are distinct from mutated memory B cells.
What's more, six species carried unique mutations, suggesting that the ability to taste sweetness had been lost repeatedly over the course of evolution.
Patterns of drug resistance in the organoids corresponded with known drug-resistance mutations, suggesting that organoids could be used to predict a person's response to a particular drug2.
However, conformational variability is seen around Leu1706 which is a hot spot for cardiomyopathy mutations suggesting that this might be important for function.
A large fraction of these flanking mutations change overall binding energies by an amount equal to or greater than consensus site mutations, suggesting that current definitions of TF binding sites may be too restrictive.
This elevation of protein-compromising URVs was several times larger than an analogously elevated rate for de novo mutations, suggesting that most rare-variant effects on schizophrenia risk are inherited.
Interestingly, 7% of MSS/MSI-L CRC bore PIK3CA mutations, suggesting that PIK3CA mutations play a role in both subsets of CRC but might represent a more important oncogenic event for the development/progression of MSI CRC than MSS CRC.
Shepherd points to previous studies showing that people with EGFR mutations survive longer under standard chemotherapy than patients without these mutations, suggesting that they might fare better regardless of their therapy.
