Sentence examples for mutations suggested to from inspiring English sources

MEFV gene mutations, suggested to be specific for familial mediterranean fever, which decrease the expression of an anti-inflammatory protein 'pyrine' from neutrophils, are also described in BD from Turkey.

In addition, it is possible that the analysis of mitochondrial DNA haplogroups may not be a suitable approach to uncover the effects of mtDNA given that different sporadic mutations suggested to be important for human longevity (see Beekman et al., 2013) fall along mtDNA molecules but are not associated with any of the haplogroups.

Given a recent study of the evolutionary trajectory of sesquiterpene cyclization promoted by epistatic active site mutations, it will be interesting to assess the degree to which cyclization-inducing mutations favored by natural selection also limit self-alkylation in comparison to mutations suggested to favor more ancient noncyclizing activity.

Thus, H230N mutation, suggested to be a gain-of-function mutation for ERK2 [26], was proved to produce partial resistance to dephosphorylation by phosphatases from HEK293 cells [27].

Although coexistent mutations of AKT1 and PIK3CA mutations are suggested to be infrequent in breast cancer (Carpten et al, 2007; Bleeker et al, 2008), it remains to be elucidated whether AKT1 mutations are mutually exclusive with all the other PI3K AKT-activating alterations in various tumour tyPI3K AKT-activating

Interestingly, these mutations are suggested to modify the severity of the HCM phenotype but not cause it per se.

Although a low expose of smoking reduces the risk for lung cancer, EGFR mutations are suggested to be related to the occurrence of lung adenocarcinoma in nonsmoker.

The effects of some of these mutations were suggested to root in a stabilization of intra-molecular base pairing in U6 snRNA.

In previous small studies of this cancer, ras mutations were suggested to be related to wood dust exposure, but these studies were too limited to detect statistically significant associations.

MAD1L1 is a component of the mitotic spindle-assembly checkpoint, and its mutations are suggested to play a role in the pathogenesis of various types of human cancer (e.g., [ 52]).

We sought mutations in the EGFR gene in TNBCs, because EGFR mutations were found in a subset of Japanese non-small lung cancers, despite being very rare in Caucasians [ 23], and because these mutations were suggested to predict responses to gefitinib therapy [ 23, 24].