Sentence examples for mutations such that from inspiring English sources

However, ~25% of cases are due to de novo mutations such that a family history is not always present [ 3].

The buffering effects of the protein-protein interaction allowed Mcm1 binding sites to acquire strengthening mutations such that sex determining genes became activated by Mcm1 alone.

The definition of R 0,k =0 is now more straightforward because we now ignore lethal deleterious mutations (such that rho_L is 0).

Therefore, environmentally induced abnormal epigenetic shifts may influence genetic mutations, such that a combination of epigenetics and genetics promotes phenotypic variation.

THRB gene sequencing confirms the diagnosis in 85% of cases, but 15% are not associated with identifiable THRB mutations, such that absence of an abnormality in this gene does not exclude the diagnosis [52].

Our current study aims to provide evidence that the BRCAx disease families are enriched with germline damaging mutations, such that focusing on each disease family will be required to determine the genetic predisposition in each family.

These data suggest that some ANTRX2 mutations, such as that identified in the long-term survivor, may be associated with a less severe course of disease.Although some aspects of systemic hyalinosis may resemble lysosomal storage disorders, the clinical features of systemic hyalinosis are distinctive, and detection of an ANTRX2 mutation can confirm the diagnosis.

Note that the NRPD2b gene is a pseudogene due to a frameshift mutation, such that the double mutant is used only as a precaution.

Both expression constructs, pKKiPGM and pKKdPGM, complemented the ΔdPGM mutation such that the colony formation at 24 hr was similar to the parental MG1655 (Fig. 6).

Although a zanamivir-sensitive isolate, A/St.Louis/758/09, carries a N163T mutation, this isolate also has a unique, nearby V189A mutation that might negate the effects of the N163T mutation such that the virus remains sensitive to zanamivir (Table 3).

That is, some other mutations may interact epistatically with the BoxG18A mutation, such that their combined benefits are less than expected from their individual effects.