Sentence examples for mutations so when from inspiring English sources
As the number of substitutions increases on each lineage, we can see that each lineage will maintain good fitness in a stabilizing landscape through compensatory changes, which each try to minimize the number of mismatches; however, each lineage fixes different sets of compensatory mutations, so when combined in a hybrid, the epistasis between pairs of sequences then gives rise to DMIs.
One reason may be that the most popular mutagen used in mouse forward genetics, ENU, induces point mutations, so when sequencing is used in these lines, two challenges arise: (1) distinguishing the ENU-induced variants from strain polymorphisms and (2) identifying real variants (either ENU-induced or strain-specific) from technical sequencing errors.
Acrylamide is known to form adducts to DNA, potentially leading to DNA mutations, so people were understandably alarmed when the compound was found in food.
Like other AAA+ enzymes TRIP13 may hold on to nucleotide during purification, even more so when it is hydrolysis-dead due to the Walker-B mutation.
It is most likely to do so when the change is modest and the amount of genetic variance (or the mutation supply rate) is high.
So when she became pregnant again, Mrs. Davis had a genetic test of the fetus, prepared to have an abortion if two mutations were found.
