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Yet even this high incidence represents only a small fraction of chromosome mutations since the vast majority are lethal and result in prenatal death or stillbirth.
We are certain these are different mutations since the SNP patterns and synonymous substitutions in the chromosomes surrounding the site are very different.
Thus, the deletion mutations most likely represent null mutations, since the resulting truncated proteins are not expected to form functional complexes with ribosomes.
The study suggested that epistasis diminished the negative effects of the individual mutations since the ability to grow at high rates contributed significantly to fitness [ 151].
(Note that we could only use 1451 rather than 1540 mutations since the remaining 89 PDs failed in at least one of the other predictors).
This correction was especially important for NANOGP10, which has accumulated 20 mutations since the H/C divergence, compared to 1 10 mutations for the other pseudogenes.
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The origin of such a relationship as in equations 1 and 2 could be traced to mutational changes in a sequence, where we restrict our analysis for the moment to transitional types of mutations since this is the dominant mode.
Current cancer genome sequencing projects are able to constrain their analysis by focusing on protein-coding regions and non-synonymous-coding mutations since that is the majority of generated data.
We studied 25 HIV newly diagnosed patients with the E138A mutation since the year 2010.
In hereditary antithrombin (AT) deficiency it is important to determine the underlying mutation since the future risk of thromboembolism varies considerably between mutations.
The EPD has alarmed Stephany's new GP with a pop-up that Stephany is carrier of a BRCA2 mutation since the clinical geneticist not only diagnosed Angela with a mutation, but unfortunately also her two daughters.
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