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At the same time, these mutations show negative epistasis in their effect on single antibiotic resistance, resulting in sign epistasis for CAZ and reciprocal sign epistasis for CTX resistance (Poelwijk et al. 2007) (Table 1).
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However, some bacterial genes show negative control.
Moreover, ccr4 mutations showed strong negative interactions with mutations in red1 and rrp6 (Fig. 6b).
Likewise, SF3B1 mutations showed independent negative prognostic value for PFS in patients receiving first-line FC and FCR treatment in the CLL8 trial 74.
In contrast, protein-truncating mutations showed evidence of negative selection, at the level of constraints on the allele fraction achieved.
Individuals who showed negative results in mutation screening were also clinically evaluated to confirm their disease status, clinical results confirmed mutation screening.
Icatibant showed negative results.
This image shows negative capacitance in action.
In addition, patients negative for nDNA mutations showed different mtDNA backgrounds.
Notably, 22% of the patients with one or more mutations showed early progressed before the third cycle compared to 7% in the triple negative group (p = 0.03).
Among the seven single-point mutations, only the A112V mutation had a negative effect on β-HCH degradation activity, while the other six mutations showed a slightly positive effect on enzymatic activity towards β-HCH (Figure 3b-h and Figure 5).
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