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Hence, by the present argument, patients with MAPT mutations should show low (normal) plasma TDP-43 levels and those with PGRN mutations should show high er) plasma TDP-43 levels.
If a large percentage of mutations are generally deleterious, then lines accumulating such mutations should show reductions in fitness across multiple fitness components, i.e., positive pleiotropy.
In theory, classifiers that predict more true somatic mutations should show higher concordance with the database of somatic mutations and lower concordance with the germline database.
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Markers that are on the opposite sides of the mutation should show recombination in different F2 or BC individuals (Appendix 1, Note 11).
For a recessive mutation, any linked SSR marker should show only the band corresponding to the mutant parent allele in the mutant pool sample, while the wild-type pool should carry both the wild-type and mutant parental alleles (Fig. 4), although there is often a faint wild-type band in the mutant pool (Appendix 1, Note 10).
Since minisatellite mutation rates are correlated with extra-pair paternity, then standard mutations (which are often replication dependent) should show a greater effect on the expression of secondary sexual characters.
Such a mutation should not exhibit unconditional positive selection in either untreated or treated samples, but should show positive conditional selection (only in the presence of the primary mutation) in both types of samples.
Still, he should show restraint.
You should show up.'".
We should show it tonight".
Sex should show an ongoing rate advantage over cloning if the external environment changes constantly to create opportunities for continuous adoption of new advantageous mutations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com