Sentence examples for mutations shift the from inspiring English sources

According to this model, familial Alzheimer's disease (FAD) PS1 mutations shift the equilibrium to favor a "close" NT-CT conformation (with NT-CT closer together) and stabilize an alignment of the PS1/γ-secretase active site with the APP substrate to favor predominant cleavage of APP at the Aβ42 position.

Thus, we assumed that additional single site mutations shift the λmax by ± 1 nm.

Signal-inverting mutations shift the equilibrium in favor of the outwardly accessible Schiff base form.

In addition, it is reasonable to assume that unknown single site mutations shift the λmax of the pigments slightly.

In addition to increasing the quantum yield and solubility of the proteins these mutations shift the spectral profiles of the translation products [ 4, 11].

We modeled this five sites rule and assumed that 5 mutations shift the λmax of the pigments by ± 7, ± 28, ± 8, ± 15, and ± 27 nm.

A weight was connected to a phenotype if mutations shifted the phenotype value by at least 0.002 (several threshold were used and gave similar results).

To examine the effect of mutation mode on the results, we also did a simulation in which all mutations shifted the λmax of the visual pigments only by ± 1.

It has also intriguingly been hypothesised that MAPT variants could impact on the type of pathology exhibited with LRRK2 mutations shifting the balance between tau and Lewy bodies [ 195, 196 ▪, 197 ▪ ].

This explains why ADP binds Kir6.2 with a lower affinity and the R50 mutation shifts the IC50 curve to a similar range of ADPβS on wild-type channels (Schwanstecher et al., 1994a; Shimomura et al., 2006).

It has been reported that the M153A mutation shifts the excitation wavelength of GFP S65T) to a longer wavelength [12].