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Structure/function relationships of the mutated sodium channels remain unclear, and most of the mutations seem to affect multiple biophysical parameters.
And these mutations seem to be especially prevalent in genes that affect neurological development and cognition.
Some mutations seem to play starring roles in one cancer while being supporting characters in another.
These somatic DNA mutations known as driver mutations seem to be the prime cause in initiating tumorigenesis.
They note that rare inherited gene mutations seem to cause Alzheimer's disease by raising amyloid levels.
Clinically, EZH2 mutations seem to commonly predict poor prognosis worse OS/leukemia-free survival (LFS), high-risk IPSS score especially in myeloid malignancies (Guglielmelli et al., 2011; Khan et al., 2013; Nikoloski et al., 2010).
The patient with PolG mutations seem to retain most junctional forms but has a drastic reduction in all dimeric mtDNA forms.
The incidence of KRAS mutations in colorectal tumors ranges from 35% to 45% [9], and KRAS mutations seem to occur early in carcinogenesis [10].
Indeed, the RAD51C mutations seem to be very rare.
These mutations seem to occur randomly and independently in each cell line.
Other mutations seem to be associated with infertility, miscarriage and prematurity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com