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Two responsible mutations resided in the C-terminal region of NS5A, G404S, and E442G and were each sufficient for low-level RBV resistance.
The mutations resided throughout the cap-binding pocket, including residues on the β1 β2 loop, and on and between the β1, β3, β5 and β6 strands with side-chains shown in the crystal structure to extend into the cap-binding pocket (Figure 1 A and B; 5 A D).
According to the sequencing results these two mutations resided in separate molecules.
None of the non-coding mutations resided in splicing donor/acceptor sites.
All mutations resided in one of three pathways (Wsp, Aws, and Mws).
Results showed that most of these point mutations resided within intergenic regions and introns.
Similar(48)
To obtain a time-averaged measure of the selective disadvantage of mutator individuals, an estimate of the average excess number of deleterious mutations residing on Mm backgrounds is required.
Several SMA patient mutations residing in the N-terminus revealed a reduction in calpain susceptibility.
Theoretically, all mutations residing in the cytoplasmic part of the receptor could influence the binding of adaptor proteins or substrates of TRKB, independent of the effect on kinase activity.
Missense mutations residing within the 12 transmembrane helices were extracted.
The hypothesis of phenotypic masking was originally focused on mutations residing in these proteins.
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