Sentence examples for mutations requires the from inspiring English sources
Functional characterization of additional thermostabilizing mutations requires the insertion of similar mutations in the wild-type receptor to allow G protein-activation tests.
We have also shown that the resistant phenotype seen with position 680 mutations requires the participation of residues outside the MPER, as well as compensatory changes within the MPER itself.
Therefore, observation of the effect of TERT promoter mutations requires the analysis of differentiated cells in which TERT down-regulation results in it becoming limiting for telomerase activity.
We found that clk-1 and isp-1 mutations induced several HIF-1 target genes and that the extended life span promoted by clk-1 and isp-1 mutations requires the HIF-1 transcription factor.
Our observation that PD mutant forms of ΔWD40-LRRK2 do not induce apoptosis indicates that these PD-linked mutations require the WD40 domain to cause neuron death.
55 These observations suggest that the genetic mutations require the specific cell type to exert cancer properties.
Both the Hx and M100081 polydactylous mutations required the spatial information encoded in the 5′ half of the ZRS to operate and, hence, the point mutations function by redirecting expression to the additional, ectopic site in the limb bud.
The relatively limited prevalence of these sensitizing mutations requires that the EGFR mutational status be verified prior to the initiation of first-line therapy with EGFR TKIs.
However, it should become clearer that a strong pruning of antigenic mutations by the joint dynamics with deleterious mutations requires that the latter contribute a substantial fraction of the average fitness variance in the population.
In practice, any test that identifies driver genes by recurrent mutations requires a good estimate of the passenger mutation probability q.
Even so, however, it is unlikely that very limited clones have a survival advantage because the Sfpi1 mutations required for the AML development are just an inactivation of the gene.
