Sentence examples for mutations required to from inspiring English sources
Understanding the rate of the ratchet is important, for example, to estimate the number of beneficial mutations required to halt the ratchet and prevent the mutational meltdown of a population (Lynch et al. 1993; Goyal et al. 2012; Pfaffelhuber et al. 2012) (for an in-depth and up-to-date discussion of the importance of deleterious mutations we refer the reader to Charlesworth 2012).
The relative importance of mutator pathways in tumorigenesis increases as the number, C, of oncogenic mutations required to generate a malignant phenotype increases, as judged by α50% values.
We report a method based on analysis of multiple sequence alignments, embodied in our program Janus, for predicting mutations required to interconvert structurally related but functionally distinct enzymes.
Cells are thought to become cancerous over many years as they collect, one by one, the mutations required to override the many genetic restraints on a cell's growth.
B The two mutations required to make the GR insensitive to aldosterone (L111Q and S106P) both make the hormone insensitive to cortisol if they occur by themselves, and it is unlikely that both arose simultaneously.
This strategy grows out of the emerging view of cancer not as a state but as a process — a decades-long trek to accumulate the six to ten genetic mutations required to turn normal cells into an invasive tumor.
For instance, most humans don't have the genetic mutation required to digest lactose.
One likely possibility is that additional mutations (1 or more, perhaps alternative mutations) are required to generate the virulent pathotype.
For some ARVs, multiple drug-resistance mutations are required to cause decreased susceptibility, while others require just a single mutation.
Mutant mice expressing Cav1.3 gain-of-function mutations are required to confirm this hypothesis.
Mutator mutations are more likely to occur early, and to occur when more oncogenic mutations are required to create a tumor.
