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Nucleophosmin-1 (NPmutationsions represent the most frequent gene alteration in acute myeloid leukemia (AML).
These mutations represent the first example of altering arrestin specificity via enhancement of the arrestin-receptor interactions rather than selective reduction of the binding to certain subtypes.
Oncogenic KRAS mutations represent the largest genomically defined subset of lung cancer, and are associated with activation of the RAS/RAF/MEK/ERK pathway.
As virtually all relapses take place in HD ALL cases within the MRD intermediate risk group, we suggest that CREBBP mutations represent the first relevant delineating parameter that allows an early prediction of potential relapses in HD ALL cases.
Nucleophosmin mutations of exon 12 (NPmutationsons) represent the most frequent molecular aberration that can be found in patients with acute myeloid leukaemia (AML) and can be detected in about 35% of AML patients.
Gain-of-function of erythropoietin receptor (EPOR) mutations represent the major cause of primary hereditary polycythemia.
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He views this as a highly effective accommodation by neurons to these genetic mutations, representing the brain's normal compensation mechanism for restoring neuronal activity.
Patients with double CEBPA mutations represented the combination of C- and N-terminal mutation types.
We found that compound heterozygous mutations represented the majority of the mutation types in all of the patients.
These values were multiplied by the colony-size ratio of sck2 relative to ade6 mutations, representing the fitness of the query.
To conclude, the present study showed that presence of KRAS mutations represents the strongest predictor for cetuximab failure in EGFR FISH-positive CRC patients.
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