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As prevalence of primary resistance of H.pylori to clarithromycin due to A2142G and A2143G mutations remains low in Marilia, the standard clarithromycin containing triple therapy is still valid.
The number of mOGCTs with documented gene mutations remains low, and most mOGCTs in DSD patients include the presence of some Y-chromosome material (59).
Although the global prevalence of pneumococcal strains with macrolide resistance conferred by ribosomal gene mutations remains low (<2%), a study of macrolide resistance mechanisms among S. pneumoniae isolated in Canada from 1997 to 2003 indicated that the rate of resistance due to mechanisms other than efflux or ribosomal methylation increased from 1% in 1997 to 10% in 2003 133).
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TDR mutation rate remains low, but the rate of TDR-associated mutations is high.
Although we have subsequently observed three BARD1 mutation carriers in our cohort since the time of data collection for this study, the mutation frequency remains low.
Though statistically significant, we note that the H3K36M mutation rate of 24% out of the 6.2% HNSC samples carrying a mutation at H3.1 remains low.
Overall and even considering a lack of sensitivity of the screening approach used in the present study, the prevalence of BRCA mutations in Sardinian families remains low.
The process of antigenic drift results in the rapid turnover of the virus population, so that despite mutation, genetic diversity among contemporaneous viruses remains low.
Although these correspond mostly to abnormalities in sperm production, the number of genetic mutations unequivocally associated with human spermatogenic impairment remains low (Visser and Repping, 2010).
Also considering some lack of sensitivity of the mutation analysis approach, the prevalence of such germline mutations among patients with familial melanoma from South Italy remains low.
This observed association between viruses and cancers, although statistically highly significant, remains low most likely because the OMIM database annotates almost exclusively inherited diseases linked to germinal mutations.
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