Sentence examples for mutations remains controversial from inspiring English sources
Owing to HA antigenic and receptor binding site overlap, the biological significance of HA-222 mutations remains controversial [20].
Predictive value of PIK3CA mutations remains controversial in that other publications have shown that these mutations have no predictive value [ 14, 15].
The prognostic value of KRAS mutations in CRC remains controversial, even though KRAS mutations have been associated with a poor response to anti-EGFR antibody therapy in metastatic CRC (Karapetis et al, 2008; Bokemeyer et al, 2009; Van Cutsem et al, 2009).
Even though routine baseline resistance mutation detection before PI therapy is still prescribed as a prognostic tool [18], the predictive value of these mutations at baseline remains controversial.
Chemotherapy as first-/second-line treatment in different epidermal growth factor receptor (EGFR) mutation lung adenocarcinoma remains controversial.
The most frequent pathogenetic mutational event in T-ALL are NOTCH1 mutations occurring in approximately 50 70% of the cases, predominantly in thymic T-ALL Although NOTCH1 mutations have been associated with an initial good response in some studies, the prognostic impact of NOTCH1 mutations in T-ALL remains controversial.
However, the prognostic impact of spliceosome gene mutations in MDS patients remains controversial [ 16].
Regarding the importance of TP53 status in this disease, there are evidences pointing to a worse prognosis for tumors with null mutations compared with those in which overexpression inducing mutations are found, although this remains controversial [ 6– 8, 10].
The role of PIK3 mutations in determining EGFR inhibitor remains controversial.
Whether sequence context determines adduct formation in specific codons in p53, that would account for the mutational spectra seen in human lung cancer, or whether this mutational spectra results from biological selection of those mutations that provide a growth advantage, remains controversial.
Whether the genetic variation needed for postzygotic isolation is segregating within species in the form of epistatic variation [3], [4] or instead arises as de novo mutations in allopatric populations [5] remains controversial.
