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The treatment of deleterious mutations remains a little confusing.
How to identify such low-frequency driver mutations remains a challenge.
Hence, discriminating background variation from causal mutations remains a major challenge.
While the interpretation of protein altering differences has progressed rapidly, the identification of cis-regulatory modifying mutations remains a challenge.
CHARACTERIZING the distribution of fitness effects (DFE) of new mutations remains a central focus in both theoretical and empirical population genetics.
Similar(55)
In her thoughtful article about her choice to undergo a double mastectomy, Angelina Jolie said the cost of genetic testing for BRCA1 and BRCA2 mutations "remains an obstacle for many women" ("My Medical Choice," Op-Ed, May 14).
However, whether p53 plays an analogous role in preventing birth defects from genetic mutations remains an unanswered question.
In addition, further evaluation of the consequences of specific CLDN16 and CLDN19 mutations remains an area for further investigation that could deliver new therapeutic strategies.
The effect of substantially altered karyotypes (typically exhibited by epithelial malignancies) on the ability to detect somatic mutations remains an open question.
The treatment of epidermal growth factor receptor (EGFR -driven non-small cEGFR -drivencers with the T790M resistance mutation remains a significell unmet medicalunged.
Whether novel sequences in cells could arise from spontaneous point mutation remains an open question.
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