Sentence examples for mutations regardless of from inspiring English sources

The optimum mutation rate depends almost exclusively on the effects of beneficial mutations regardless of the extent of deleterious mutation effects.

For each tumor sample, we used all base substitution mutations, regardless of their effect, to calculate the relative frequencies of the six different classes of single base substitutions.

Counting the number of patients with mutations, regardless of type of gene or multiple mutations in the same gene, revealed no difference between the two tumour groups.

For the purposes of this review, we consider sequence changes in genes that affect transcript structure or abundance to be mutations, regardless of their allele frequencies.

The cancer rates published by Antoniou et al (2003) are based on measurements obtained from a population that was tested for BRCA mutations regardless of family history.

Mutations such as E255K are also associated with significantly shorter survival rates than other mutations, regardless of their sensitivity to imatinib (Griswold et al, 2006), resulting in a more aggressive phenotype.

7 It is noteworthy that loss of immunohistochemical (IHC) staining for SDHB has been consistently identified in pheochromocytomas/paragangliomas, 8,9 GISTs, 6,10 14 and renal carcinomas 7,15 associated with SDH mutation regardless of which SDH subunit is mutated.

They wanted to create a "basket" of patients—individuals who possessed the mutation, regardless of the kind of cancer and then treat them with the drug.

Importantly, we identified an increased number of iCNA in tumours harbouring an H3F3A K27mutationon, regardless of anatomical location.

We observed an association between polyunsaturated fat intake, especially linoleic acid, and increased risk of colon tumors with a KRAS mutation, regardless of the type of mutations [ 22].

This system has enormous benefits, as it is based on the outcome of the mutation regardless of the initial biological function of the gene.