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Such a library would correctly identify more sequence variants than a traditional tiling library with variation at the single position where multiple mutations occur frequently within single probes and those mutations reflect a limited set of possible variants.
This model argues that changes to mandibular and maxillary skeletal elements in mice mutant for various Dlx gene mutations, reflect a transformation of the upper and lower jaws due to a loss of signals from the 'caps' at the ends of the jaws to the 'hinges'hinges
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These nupts have significantly accumulated GC-to-AT mutations, reflecting a nuclear mutational environment shaped by spontaneous deamination of 5-methylcytosin.
It is however imperative to ensure high-tumor percentage in tissues examine to ensure that a lack of mutations reflects a true negative result rather than false negatives due to a high proportion of normal cells.
Fresh DNA presumably lacks measurable DNA damage, and therefore mutations reflect polymerase fidelity, or the ability to match the correct base opposite a normal base.
The lack of deleterious germline mutations could reflect a fundamental role for ATR in cell viability, including DNA replication [ 5].
Selective pressure analysis predicted that most of these mutations reflect positive selection.
Benign mutations (as the combination of silent and LoFI) mutations reflect the background mutation rate of each gene.
By comparing three different lab-strains we show that spontaneously generated mutations reflect genome composition, without nucleotide bias.
We therefore assume that the observed effects of the mutations reflect alterations in protein functional activity and not levels.
In the absence of recombination, the NRY passes mostly unchanged from father to son and observed mutations reflect the evolutionary history of the Y chromosome.
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