Sentence examples for mutations reduced the from inspiring English sources

Computational modeling of the experimentally identified mutations showed that these mutations reduced the binding affinity through one of the three scenarios: through SCF destabilization, through elimination of favorable SCF/c-Kit intermolecular interactions, or through allosteric changes.

The increase in active site hydrophobicity that was caused from the W359F and M375I mutations reduced the concentration of maltotriose required for use as a donor/acceptor for transglycosylation to 100 mM and 50 mM, respectively, compared to the 200 mM needed for wild-type.

In all cases, however, the substitution mutations reduced the frequency of termination-reinitiation events, albeit to a lesser extent with the 3' complementary extension mutant (Figure 3A).

In line with this, the phospho-mimetic mutations reduced the affinity for Hsp70 while not affecting the interaction with Hsp90.

We found that all mutations reduced the mRNA level and the reduction was clearly suppressed in the upf2Δ strain.

Both mutations reduced the peak Na+ current density due to limited trafficking of the SCN5A protein towards the membrane, but Gly1748Asp also profoundly affected channel gating.

Moreover, the reduced hydroxylase activity due to the chy1, chy2 and lut5 mutations, reduces the rate of β-carotene processing into downstream xanthophylls, favoring its accumulation.

On the other hand, mutations reduce the information content passed from generation to generation, thereby reducing the efficiency of selection.

In addition, some ALS-causing mutations reduce the affinity of the SOD protein for its zinc cofactor [41].

All these mutations reduce the ability of the receptor to respond to α-MSH (data not shown and [26], [32] [34].

The analysis of Figure 2 shows that 18 mutations reduce the susceptibility to one or several NRTIs by more than 0.2 log units.