3) The effect of deleterious mutations: In the Discussion, the authors argue that the presence of deleterious mutations reduce clonal competition compared to populations without mutational load.
Therefore, AtPIP1 4 mutations reduce Arabidopsis growth and further arrest the promoting effect of Hpa1.
Recurrent missense mutations reduce Pou2f2 transactivation activity and B lymphoma cell lines expressing these have a survival advantage20, conversely DLBCL cell lines appear to be addicted to POU2F2 exPOU2F2on21.
We further show that pocket mutations reduce phospholipid binding and receptor activity in vivo.
mop2 mutations reduce the abundance and activity of Pma1 protein on the plasma membrane without affecting the abundance of other prominent plasma membrane proteins.
Thus, the NKD1 mutations reduce Nkd1/Dvl associations in vitro and in vivo.
Many pathogenic mutations reduce hPGRN levels, indicating a haploinsufficiency pathogenic mechanism [7], [8].
Similarly, ico missense mutations reduce DPP signaling in embryos (Figure 1).
On the other hand, mutations reduce the information content passed from generation to generation, thereby reducing the efficiency of selection.
It is possible then, that enz mutations reduce chromatophore proliferation resulting in a smaller population of pigment cells.
