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Two enzymatic properties of ERAP1 have been recognized thus far that can help scientists understand its role in antigen presentation.
Ideally, all of the species recognized thus far should have a place in that phylogenetic tree.
Homeskim recognizes that thus far there is no location finder that can address the needs of all these different people.
All PCa-associated SPOP mutations discovered thus far affect evolutionarily conserved residues within the MATH domain and alter its ability to bind substrates8,9,10.
In a new study published online Sept. 21 in Neuron, the researchers show that this mutation, found within a gene called C9ORF72, is about twice as common as all the other mutations discovered thus far for the disease combined.
However, no tau mutations have thus far been observed in AD.
Heterozygous missense mutations have thus far been reported in only 60% of MWS patients analysed [ 4].
Biallelic germline and somatic CCM1 mutations have thus far only been reported once.
Eight ACTN2 mutations have thus far been linked to HCM, DCM and/or other cardiac abnormalities.
All the SPOP mutations found thus far occur in the MATH domain, a substrate-binding motif (Zhuang et al., 2009).
Interestingly, all SPOP mutations described thus far affect evolutionarily conserved residues in the structurally defined substrate-binding MATH domain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com