The defects may be the result of several minor genetic mutations rather than the single mutation that produces seizures in the rare, highly heritable forms of epilepsy.
The most distinctive feature of the approach taken is an emphasis on extensive screening for rare disease-causing mutations rather than common risk-increasing polymorphisms.
Our results for H5N1 show that in most cases drug resistance has arisen by independent point mutations rather than reassortment or covariation.
Instead, current evidence suggests that the oncogenic viruses implicated in some human cancers facilitate genetic mutations rather than cause them directly.
Allison Kurian and her colleagues found that more women with breast cancer are getting genetic tests that can detect multiple cancer-associated mutations rather than being tested only for mutations in the BRCA1 and BRCA2 genes.
Throughout the remaining analyses we focus mainly on efflux-related mutations, rather than resistance group, to explicitly address putative mechanisms of resistance, and relative fitness rather than growth rate.
(The sudden fall-off at the end is caused because the linkage-disequilibrium method cannot easily detect very recent mutations, rather than by a sudden reduction in the rate of evolution).
That same year he and Delbrück devised the fluctuation test, which provided experimental evidence that phage-resistant bacteria were the result of spontaneous mutations rather than a direct response to changes in the environment.
Achondroplasia is inherited as an autosomal dominant trait; about 80 percent of cases of the disorder result from new genetic mutations rather than from the parental transmission of defective genes.
Similarly, the most deadly type of brain cancer (glioma) may primarily be due to random mutations rather than to environmental exposures, including cell phone use.
The results, in the journal Science, showed two thirds of the cancer types analysed were caused just by chance mutations rather than lifestyle.
