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The number of somatic mutations ranged from 743 to 3910.
In contrast, the frequency of p53 mutations ranged from 44.2% to 48.7% in virus-unrelated HNSCCs.
Transmission rates for nonfunctional mutations ranged from 13to90%0% for the other 12 gRNA-e lines.
We noticed that the frequency of EGFR mutations ranged from 8% in Caucasian patients to 30% in Asian patients.
The frequency of T to A and A to T transversions, the second most frequently observed group of mutations, ranged from 12 to 33%%.
In this study, the frequency of BRCA1/2 mutations ranged from ~8 to ~16% across four subtypes of breast cancer as defined by immunohistochemistry subtyping.
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PIK3CA is the most frequently mutated oncogene in human breast cancers and shows activating mutations ranging from 10% in the triple-negative subgroup to 40% in the hormonal receptor-positive/ERBB2-negative subgroups.
CRISPR/Cas9 (CRISPR-associated protein 9) genome editing has been used to correct disease-causing DNA mutations ranging from a single base pair to large deletions in model systems ranging from cells in vitro to animals in vivo.
Similar to the spectrum of hematological findings associated with telomerase mutations, ranging from isolated macrocytosis to acute myeloid leukemia, liver disease was heterogeneous in severity and pathology among telomerase-mutation carriers.
The degree of penetrance of this EVE neural phenotype is variable: all Df(1 446-20 embryos show at least two missing RP2s whereas Ppt1A179T and Ppt1S77F point mutations range from 32 50%.
To determine the in vivo function of PiT1, we targeted the PiT1 locus by homologous recombination in ES cells and generated an allelic series of mutations ranging from mild impairment to elimination of PiT1 function.
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Justyna Jupowicz-Kozak
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