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This mutation has been detected exclusively in B-ALL and almost always in association with mutations in the CRLF2 gene 15, thereby suggesting that these mutations provide an advantage to B-lineage commitment, perhaps by inducing a weaker signal that preferentially activates only one signaling pathway.
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Because each lineage of Y chromosomes carries its own signature set of DNA changes, these mutations provide a perfect system for tracking male genealogies, and that is what Dr. Sykes looked for in the cotton swabs mailed back to him.
Further analysis revealed that rbf1 mutations provide a sensitized genetic background for Psc-induced developmental defects.
Mutations provide a continuous source of variation in natural populations, on which natural selection can act.
The novel collagen mutations provide a valuable addition to the set of known mutations available for studying genotype phenotype relationships.
PIK/AKT mutations provide a cell with the abilities to evade apoptosis and survive hypoxic and avascular conditions.
In this work, we demonstrate how anticodon mutations provide a rapid mechanism to alter the tRNA pool.
All three mutations provide a strong fitness benefit under Pi-limitation and in BW4218 or BW4227, the rpoS mutation was the dominant fitness determinant in the isolate (fig. 3 A ).
Driver mutations provide a growth advantage for tumor cells and have been positively selected during the evolution of a cancer [ 1].
Thus, these mutations provide a broad portfolio of potentially exploitable TSAs for future studies.> -wrap-foot> The bold letters signify the mutated amino acid.
Validation of the affected molecular pathways, described here such as abnormal iron homeostasis or β-catenin dysregulation could also, in an animal model of KDM5C mutations, provide a framework for potential therapeutic developments for patients with KDM5C mutations.
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