Sentence examples for mutations present only from inspiring English sources
In contrast, the ratio decreased to 0.8 (5/6) for the mutations present only in single individual.
However, repeat biopsies are difficult, invasive, costly and somewhat limited in that they provide a picture of mutations present only at a given time and organ site [ 55].
Our goal was the identification of mutations present only in the affected twins, pointing to novel candidates for CD susceptibility loci.
On the other hand, mutations present only in some regions of the bowel would be rather unlikely to have an effect on the development of Crohn's disease.
Heteroplasmic mitochondrial DNA (mtDNA) mutations (mutations present only in a subset of cellular mtDNA copies) arise de novo during the normal ageing process or may be maternally inherited in pedigrees with mitochondrial disease syndromes.
To establish a variant difference cutoff we leveraged the validation results of 121 potential somatic alleles 67 of which were confirmed to be genuine somatic mutations present only in the tumor samples.
However, this large deletion seems to be a founder mutation present only in Slavic populations.
It is noteworthy that the A72G mutation, present only in a laboratory mutant strain, was found to occur between the predicted −35 and −10 promoter sequences.
5) The variants shared between the father (#9, #10) and their daughters (#5, #6, #7) were removed upon Sanger sequencing validation; 6) All the remaining variants were validated by Sanger sequencing to confirm that each variant is a real germline mutation present only in the breast cancer-affected members.
Eight of the dolutegravir failures and 18 of the raltegravir failures had integrase genotyping reported, showing that mutations were present only in the raltegravir group, one with integrase inhibitor-associated resistance (N155H) and four with NRTI mutations.
Analysis of three to four tumor-specific somatic mutations will be helpful to rule out signal deriving partially from non-neoplastic cells or from somatic mutations present in only a subset of the neoplasm.
