Sentence examples for mutations predisposing to from inspiring English sources

Vinyl chloride exposure induces mutations in K-Ras, hepatocyte nuclear factor 1α (HNF1 α) mutations associated with hepatocellular adenomas and adenomatosis polyposis coli (APC) germline mutations predisposing to hepatoblastomas.

Our study was looking for germ-line mutations predisposing to another specific nephropathy-Balkan endemic nephropathy.

This is now changing as psychiatric genetics reveals more and more specific mutations predisposing to psychiatric disease.

Other ACTA2 mutations predisposing to stroke have been reported, such as those resulting in R258C/H and R39H changes [ 7].

Heritable mutations predisposing to male breast cancer include BRCA2, BRCA1 and, possibly, the androgen receptor gene (Lynch et al, 1999; Liede et al, 2004).

They contributed essential knowledge about the epidemiology of mutations predisposing to cancer, and they significantly advanced knowledge about appropriate ways to manage inherited cancer risks.

In HCA, CTNNB1 mutations predispose to transformation of HCA in HCC and TERT promoter mutations are required in most of the cases as a second hit for a full malignant transformation.

All of these genes play a role in the RANK-NFκB signalling pathway and it is likely that the mutations predispose to PDB by disrupting normal signalling, leading to osteoclast activation.

Whether PGL gene mutations predispose to non-paraganglionic tumors or system abnormalities is a subject of ongoing investigations [8], [9].

Germline BMPR1A mutations predispose to juvenile polyposis syndrome; however, our findings indicate that also somatic mutations might play an important role in sporadic colorectal cancer development [29], [30], [31], [32], [33].

MUTYH mutations predispose to recessively inherited colorectal polyposis and cancer.