Sentence examples for mutations predicted to from inspiring English sources

This is a difficult problem because mutations predicted to destabilize the negative state might be accommodated by small conformational rearrangements.

The combinations of mutations predicted to yield global optima for desired functions can then be selected and introduced into the enzymes.

Using the FoldX protein design algorithm, we generated eight NGF variants with different point mutations predicted to have altered binding to TrkA or p75NTR.

Point mutations predicted to be favorable include Arg to His or Trp substitutions at position 2 and a Phe to Tyr substitution at position 3 of the hexapeptide.

Birds who had pharmacologically elevated levels of mTOR activation demonstrated less engagement with the adults, similar to what has been observed in children diagnosed with autism spectrum disorders, who often have mutations predicted to increase levels of mTOR signaling.

Lewinsohn et al. identified five novel mutations including missense mutations within important functional domains, and splicing mutations predicted to result in truncated proteins from a family with MDS/AML (Lewinsohn et al., 2016).

Mutations predicted to specifically disrupt inter-helical contacts or tertiary structure of ERev were introduced into the Rev expression vector pcH21SL using PCR-based site-directed mutagenesis25.

In addition, the proportion of missense mutations predicted to be probably damaging was almost twice that predicted to be possibly damaging (49.7% vs 23.8%).

Mutations predicted to prevent this interaction inhibit homo-oligomerization and prevent Gro from repressing transcription in vitro and in vivo [18], [19], [20].

Comprehensive analysis of KRIT1 gene in patients with CCMs has led to the identification of more than 90 distinct mutations predicted to lead mainly to a premature stop codon [2], [18], suggesting that KRIT1 function needs to be severely impaired for pathogenesis.

Accumulation of mutations predicted to disrupt protein-coding genes after 300 generations of propagation.