Sentence examples for mutations potentiate a from inspiring English sources

We propose that KRAS mutations potentiate a signaling network that is promoted by environmental factors.

The protective effect of FKBP52 on Aβ toxicity during Drosophila aging was evident from the observations that FKBP52 loss of function mutations potentiated Aβ toxicity, while over-expression of FKBP52 delayed or suppressed Aβ-induced phenotypes.

Collectively, these efflux transporters potentiate a much broader antimicrobial tolerance.

Interestingly, the T48I mutation potentiates CAMP activation in the phoQ T48I W104C-A128C background by an unknown mechanism.

(B ) The initial gltA1 mutation potentiated the evolution of Cit+.

Thus, the gltA1 mutation potentiated the eventual evolution of robust citrate utilization (Cit++) by preventing the citT mutation from having deleterious effects when it first appeared.

36 The significantly decreased [H]-DA uptake in reserpine-treated KI/KI striatal synaptosomes (Fig. 6B) indicates that LRRK2R1441G mutation potentiates DA depletion in striatum by suppressing uptake of extracellular DA in mutant presynaptic terminals.

We were then able to compare differences in growth and fitness between ZDB564 and ZDB706 variants with and without the evolved gltA1 allele, and thereby test whether this citrate synthase mutation potentiated the evolution Cit+ by altering the effects of the citT actualizing mutation.

Is has also been observed that NPs potentiate an inflammatory response in subjects with lung inflammation.

At high micromolar concentrations 5-HT3A recurrentscurrents are competitively inhibited by topotecan while 5-HT3AB recurrentsurrents are potentiated, a property that is influenced by a 5-HT3B subunit mutation (Y129C) that lies outside of the binding site (Nakamura et al., 2013).

The significantly larger double mutation rate of NOD2 and PSMG1 variants in the CD group (60%) compared with the control group (18%) may also suggest that NOD2 mutations affect NF-kappaB signalling and PSMG1 mutations may potentiate microbial-triggered inflammation in CD patients.