Sentence examples for mutations pose a from inspiring English sources
All of these mutations pose a serious challenge for the proteostasis network as they result not only in impaired function of the respective protein but also in ER stress, dysregulated proteasome, and altered autophagy function [25]-[27] [25]-[27]
It remains to be characterized whether the presence of these relatively common mutations poses a risk for peripheral arterial disease (PAD).
However, the genomic heterogeneity of these resistance mutations poses a pharmacological challenge to develop selective KIT inhibitors that inhibit all possible mutations (Wardelmann et al, 2005).
Because of rapid increase in detection of the TR34/L98H mutation in many regions and its adverse effect on patient management, isolates harboring this mutation pose a serious public health threat.
The emergence of NAI-resistant variants of H7N9viruses with an NA R292K mutation poses a therapeutic challenge.
Particularly high background noise and artificial T > C substitutions at the position of the p.V654A mutation posed a problem and led to a higher detection limit.
The variable expression of phenotypes, even among patients with the same GNAS mutation, poses a challenging problem and suggests a role of other genetic loci, epigenetic modifications, or environmental factors.
Deletion and insertion mutations pose additional challenges to be addressed in a future version.
So are vaccines for such vexing diseases as AIDS, a big killer whose variety and rapid mutations pose hard problems for vaccine makers.
Given the breadth of MPS gene interrogation, it is reasonable to anticipate that occasional participants may have mutations that pose a likely severe negative consequence, which we classify as "panic" results.
Repeat expansion mutations pose specific database issues [Martindale et al., 2012] and all pathological expansions of the noncoding G4C2 repeat in the C9orf72 promoter leading to FTLD and amyotrophic lateral sclerosis (ALS) are considered the same mutation.
