Sentence examples for mutations play important from inspiring English sources

Low-level DNA mutations play important roles in cancer prognosis and treatment.

It is widely believed that somatic as well as germline mutations play important roles in the origin and progression of colorectal cancers (Calvert and Frucht, 2002).

For example, using iPSCs generated from the fibroblasts of a patient with Rett syndrome (RTT) as models, investigators identified an unexplored critical window at the early stage of neural development, during which subtle alterations in the nervous system, found to be caused by MeCP2 mutations, play important roles in the initiation of RTT [33].

In this study, we conducted such analyses and present strong evidence that regulatory mutations played important roles in recent and ongoing human adaptation to local environment.

They also discussed the structural and functional consequences of these processes and concluded that certain compensatory replacement mutations could play important role in the fixation of the functionally novel mutations.

Although, as we will see later, dominant mutations could play important roles in further steps of the speciation process, i.e. in reinforcement, it is thus hard to envisage how they could, on their own, promote the selection of reproductive barriers with the ancestral stock.

Two types of genetic mutation play important roles in pancreatic cancer.

Comparative analyses suggest that gene duplication, gene conversion, and variable exon mutation play important roles in vertebrate Pcdh evolution [ 3- 5].

Study of mutagenesis has assumed importance due to the fact that mutations play an important role in carcinogenesis [ 6].

Overall, somatic mutations located in protein pocket regions could be functional mutations in cancer, and play important roles during tumorigenesis and for anticancer drug responses.

In cancer, germline mutations play an important role in the establishment of tumor pathways.