Sentence examples for mutations owing to from inspiring English sources

However, we recognize that our summary may not contain all Nav channel disease-related mutations owing to abundant literatures reporting Nav channel disease-related mutations and increasing volume of work describing new findings.

Though, we could confirm the causal gene, the causal mutation could not be ascertained as we could not identify any recombinants in the material tested among the five potential causal mutations, owing to small population size.

However, human and mouse may be more tolerant for such mutations owing to the prominent presence of the enzyme chitobiase.

We first screened the proband for SCN5A mutations owing to their known association with familial SSS (Lei et al. 2007).

The mismatch repair (MMR) system was originally identified in bacteria, and its inactivation results in an increase in the rate of spontaneous mutations owing to the inability to repair the replication errors.

In 15% of patients single monomorphic ventricular premature beats were detected and identified to be linked to RyR2 mutations owing to the presence of sudden deaths of their family members and subsequent family screening.

All cell lines carry a homozygous WT1 mutation owing to loss of heterozygosity of 11p markers.

We note that two patients were missing either KRAS or BRAF data; however, they were classified as having a pathway mutation owing to harbouring a PIK3CA mutation.

In this respect, a timely theory of adaptive evolution must recognize the importance of phenotypic accommodation, that is, the refinement of the adaptive phenotype through subsequent mutational changes (Suzuki and Nijhout, 2006), in addition to selection operating on novel features arising from random variation owing to mutation (West-Eberhard, 2005b).

Here we tested for associations with grade, stage, gender and other mutations both with and without these mutations included, owing to this uncertainty.

These data suggest that expression of constitutively activated BRAF uniquely predicts sensitivity to MEK inhibition compared to tumours with RAS mutations, perhaps owing to RAS-mediated activation of signalling molecules not in the linear RAS RAF cascade.