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This could be because the effects of the mutations overlap, so that cells with both mutations have no advantages over cells with just one.
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"We overlap so much.
How can two contrasting categories overlap so much?
First, the spectrum of CFC and nevi/cancer mutations overlap, some with identical mutations.
The genes that encode the polymerase and envelope proteins of HBV overlap, so resistance mutations in polymerase usually affect the hepatitis B surface antigen; these alterations affect infectivity, vaccine efficacy, pathogenesis of liver disease, and transmission throughout the population.
There was no geographic overlap, so secondary clusters would not overlap the most likely cluster.
The data bases largely overlap, so we could combine them.
The single KRAS mutation overlapped with one p53 mutation.
This suggests that the mutations exert overlapping cellular functions.
You'd made mutations look so good".
For a moment, imagine all women with the BRCA mutations did so.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com